Recommended annual blood tests. Part-3

Introduction: Hi, guys in this part of series  I am going to talk about KFT(kidney function test). Now days kidney related diseases are became so common and because of lifestyle is showing early stages of our life span. Kidney disease are not at all related to age, it can happen to any age group of people. One really important thing is any problem related to kidney shows after 50% damage. So, we have to more caution regarding this issue. 
                      Picture of Kidney

Why kidney Play important for body- 
       It's a small bean like structure and weight is 150 gm in male and 135 in female approximately. It's play a role in filtration different body waste fluid like urea from blood and it also maintain different chemical like sodium, potassium, chloride and phosphorus. It's also prevents removal of hemoglobin. In a day kidney nearly filter whole blood and eliminate all the unnecessary substance.

Tests are included in KFT/RFT:
1. Urea.
2. Creatinine.
3. Uric acid.
4. Sodium.
5. Potassium.
6. Chloride.
7. Phosphorus.
8. BUN( blood urea nitrogen).
9. GFR (glomerular filtration rate).
10. Urine protein test.
         
Biochemistry full auto analyser


Not all these tests are required primary assessment; only urea, creatinine and uriv acid is enough for the assessment. In different conditions it's change like for normal assessment creatinine and urine protein is showing better results companies to other expensive tests. 

About the tests: 
Urea- It is end product of amino acid metabolism. Amino acid is harmful for our body, in the liver convert into urea. Because of urea cycle amonia covert into urea and through the blood it's reach to kidney and there urea eliminate from our body but a small amount of urea reabsorb in by kidney. In case of kidney disfunction blood urea level increase. Normal level of urea in our blood is 10-40 mg/dl.
       
Creatinine- Creatinine is excreted from our muscles, it is excrition product of ceatine phosphate. Creatinine is not influenced by body metabolism or dietary factors. Creatinine is filtered by glomeruli and samll an amount by tubules. Because of it creatinine and GFR results are more close to other, hence it is more sensitive test for diagnosis of kidney function. Normal level of serum creatinine in male  0.6-1.5 mg/dl and in female 0.6-1.3 mg/dl

Uric acid- It is an end product of purine metabolism. Hyperuricemia leads to elevation of serum uric acid concentration. Because of uric acid urate crystal from in the body and those crystals are pass through the kidney, while passing it can cause damage or scars; not only the is can also cause gout in our joints. Normal level of uric acid in male 3-7 mg/dl and in female 2.5-6 mg/dl.
Deformations of bone in legs because of gout

Electrolytes- Sodium, potassium and chloride are essential for our body, because it maintain our body fluids and pH of body. For the filtration of blood proper amount of fluid require, without proper fluid balance kidney cannot function properly. Normal level of sodium 135-145 mmol/L, potassium 3.5-5 mmol/L and chloride 95-107 mmol/L.
   
Phosphorus-  In several kidney diseases phosphorus level elevate and cause acidosis (decrease in blood pH leads to acid nature of blood). Renal rickets is associated with low phosphorus level. Normal level of phosphorus is 3-4 mg/dl.

GFR- About 120-125 ml/min blood filter through kidney and this is reffer to as glomerular filtration rate. In an adult about 175-180 litter/day outof it only 1.5 litter/day excited as urine. It means around 99% reabsorb by kidney. Normal level of GFR is 90-120 ml/min, by the age level decrease.

Urine protein test- In a healthy individual urine does not contain protein. In case of kidney disease protein levels are found in urine. Normal it's absent but if it is more than 30 mg/dl maybe the symptom kidney disease.

Few more tests are done for the diagnosis of kidney function like ABG analysis, microabomin. According to medical conditions physician prescribe different test.
  To prevent kidney disease we have to lookout our diet, consumption of water, before taking muscle building supplements I have to consult with nutritionist. 
  
So, that is it for today. 

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1 Comments

  1. Nice writing. Thanks for providing all these information.

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